Endocrine Abstracts

IntroductionThe importance of calcium intake from dairy has been investigated in several studies with discrepant results. Meta-analyses have shown beneficial effects of dairy intake on cardiovascular health with an inverse association between intake and cardiovascular disease. However, a recent trial has suggested an increase in blood pressure in the hours following intake of 1000 mg of calcium citrate compared with placebo. So far, it has not been inves...

Introduction: Hereditary hypophosphatemia (HH) are rare diseases, characterized by increased levels of fibroblast growth factor 23 (FGF23), excessive renal phosphate wasting and inappropriately low 1,25-dihydroxy-vitamin D causing hypophosphatemia. In children, the diseases manifest as rickets and osteomalacia, in adults only osteomalacia. Studies in cardiovascular risk among patients with HH are few and inconclusive. Some have found left ventricular hypertrophy in children an...

Background and objectiveAn increased risk of fractures in Primary Hyperparathyroidism (PHPT) has been reported in a number of relatively small studies. Performing a systematic literature search we identified available studies and calculated common estimates by pooling results from the individual studies in a meta-analysis.Methods: Searching EMBASE and PubMed using both free text word search and Mesh terms we identified published st...

Conventional therapy for chronic hypoparathyroidism is oral calcium and active vitamin D; despite treatment, chronic hypoparathyroidism may be associated with increased risk of renal complications. Without the effect of parathyroid hormone on renal tubular reabsorption, calcium-conserving and phosphaturic effects are lost, serum calcium levels are reduced and serum phosphate levels are increased. This may lead to hypercalciuria and hyperphosphataemia, which may be associated w...

Introduction: Vitamin D insufficiency (25-hydroxy vitamin D <50 nmol/l) is a global health problem. Vitamin D food fortification might be the solution, but knowledge is sparse on whether fortification of various food items affects the bioavailability differently. It is generally assumed that ingesting vitamin D with a fatty meal improves the bioavailability of vitamin D. Furthermore, complex formation with whey protein isolate (WPI) may enhance the stability of vitamin D a...

Objective: Vitamin D has potential immunomodulatory effects. We studied whether vitamin D3 supplementation affects the course of Graves’ disease (GD).Methods: In a double-blind, placebo-controlled design, we randomized patients with a first time diagnosis of GD hyperthyroidism to daily supplementation with vitamin D3 70 mg (2800 IU) or placebo, as add-on to standard treatment with anti-thyroid drugs (ATD). The intervention was continued 12 months af...

Introduction: Multiple adverse health outcomes are reported in response to low vitamin D and/or hyperparathyroidism.Aim and methods: A cross-sectional study in a random sample of mainly non-vitamin D supplemented Danish women (N=1580) during winter-time. We investigated prevalence of vitamin D insufficiency, hyperparathyroidism, general health and quality of life (QoL) as assessed by a general health questionnaire and a validated hyperparathyroi...

Background: Vitamin D is important to skeletal health and is standard care in conditions with low BMD. Thyrotoxicosis caused by Graves’ disease (GD) leads to increased bone turnover and reduced BMD. We aimed to test the hypothesis that vitamin D supplementation would improve bone recovery in GD.Methods: Using a double-blinded design, hyperthyroid patients with a first time diagnosis of GD were randomized to supplementation with vitamin D3 70 mg/day...

This study investigated risk of cardiovascular (CV) events over a period of up to 5 years in adult patients with chronic hypoparathyroidism treated with recombinant human parathyroid hormone (1–84), rhPTH(1–84), compared with a historical control cohort of patients who did not receive rhPTH(1––84). The rhPTH(1–84)-treated patient cohort was derived from the NCT00732615 (REPLACE), NCT01...

Changes in estimated glomerular filtration rate (eGFR) over 5 years were evaluated in adult patients with chronic hypoparathyroidism. A cohort of patients treated with recombinant human parathyroid hormone (1–84), rhPTH(1–84), was derived from NCT01297309 (RACE) and NCT01199614 (HEXT) clinical trials. A historical control patient cohort with hypoparathyroidism who did not receive rhPTH(1–84) or rhPTH(1&#...